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KMID : 1123920020160010181
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Korean Journal of Oriental Physiology and Pathology
2002 Volume.16 No. 1 p.181 ~ p.185
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A study on anti-thrombotic activity of Hwao-tang
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Park Tae-Woo
Park Won-Hwan
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Abstract
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The thrombosis is the category of blood stasis. Blood stasis is a pathologicial state resulting from the reverse or impeded flow of blood in the body or the stagnation of blood flow in local parts as well as abnormal blood outside of the vessles which remains in the body and fails to disperse. Hwao-tang has been reported to have a hypolipidemic effect in patients with hypercholesterolemia, and in highcholesterol-induced experimental models. The present paper reports the effects of HOT on atherosclerosis using a spontaneous experimental model, Kurosawa and Kusanagi-hypercholesterolemic (KHC) rabbits. We have also investigated the pharmacological effect of extracts obtained from HOT on collagen-and ADP-induced blood platelet aggregation, thrombin-induced conversion of fibrinogen and fibrinolysis in in vitro experiments. In conclusion, the protection of extracts of Korean herbs’ HOT on the ischemic infarction induced artificially might be involved to their inhibition of thrombotic action.
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KEYWORD
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Hwao-tang(化瘀湯), thrombosis, blood stasis, atherosclerosis, hypercholesterolia, collagen, ADP
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